Low voltage tube RF preamplifier
The biggest disadvantage
when operating tubes on high voltages is not the high voltage PSU, this
can be relatively easy to build. The biggest disadvantage is that most
of the other components in the circuit must be also of high voltage.
This increases the cost at a geometric rate, since one cannot use
common modern low voltage components anymore. When the specific
application you build, operates on low signal handling, then it
perfectly fine to use low anode voltages in some stages and then use
high voltage only when great amplification is needed and not throughout
the whole circuit.
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